Avtor/Urednik		Gruden, Nevenka; Stantić, Mirjana; Buben, Mirka
Naslov		Influence of lead on calcium and strontium transfer through the duodenal wall in rats
Tip		članek
Vir		Environ Res
Vol. in št.		Letnik 8, št. 2
Leto izdaje		1974
Obseg		str. 203-6
Jezik		eng
Abstrakt		Five-week-old female albino rats were given daily doses for 1 or 2 weeks of lead as acetate ranging from 2 micro g to 40 mg by gastric intubation and sacrificed on the 8th or 15th day of the experiment. Calcium-45 and 85Sr were used as markers to assess the calcium and strontium transfer through the duodenal wall by the everted gut sac method of Wilson and Wiseman. Doses of lead acetate greater than 20 micro g per day decreased the transfer of both calcium and strontium across the duodenal wall and these transfers decreased further with increased doses of lead, an effect which was independent of whether the rats were killed on the 8th or 15th day of the experiment. Doses of lead acetate greater than 200 micro g per day, however, did not produce a further decrease in these transfers. The retention of both calcium and strontium in the intestinal wall was unaffected by the lead treatment.
Deskriptorji		CALCIUM LEAD DUODENUM INTESTINAL ABSORPTION STRONTIUM RATS ACETATES BIOLOGICAL TRANSPORT CALCIUM RADIOISOTOPES DOSE-RESPONSE RELATIONSHIP, DRUG INTUBATION, GASTROINTESTINAL STRONTIUM RADIOISOTOPES