Avtor/Urednik		Meden-Vrtovec, Helena; Močnik-Rožnik, Sonja; Tomaževič, Tomaž; Virant-Klun, Irma
Naslov		Recombinant FSH vs. urinary FSH for ovarian stimulation in in vitro fertilization
Tip		članek
Vir		J Reprod Med
Vol. in št.		Letnik 48, št. 10
Leto izdaje		2003
Obseg		str. 799-803
Jezik		eng
Abstrakt		Objective: To compare ovarian stimulation with recombinant FSH (rFSH) vs. urinary FSH (uFSH) in terms of hormonal events within ovarian follicles and the outcome of in vitro fertilization. Study design: A prospective randomized comparative study of rFSH (n = 70) vs. uFSH (n = 61) ovarian stimulation. Hormone determinations were serum estradiol (E2) on the day of human chorionic gonadotropin (hCG) administration, and E2, androstenedione (A) and testosterone (T) at the time of follicular aspiration in the follicular fluid and serum. Results: The total dose of gonadotropins required and the length of ovarian stimulation were the same in the 2 groups. In follicular fluid the E2 and the A levels were significantly higher in the rFSHgroup (3,065+- 1,646 vs. 2,368 +- 1,240 nmol/L, P = .004, and 103.7 ± 51.6 vs. 89.0 ± 42.3 nmol/L, P = .042, respectively), whereas A: E2 and T:E2 ratios were significantly lower (39.6+-22.5 vs. 52.3 +- 59.6, P = .042, and 9.1 +- 4. 7 vs. 17.6 +- 26.9, P = .006, respectively). Serum hormonal levels, number of oocytes retrieved and pregnancy rates did not differ significantly between the groups. Conclusion: rFSH provides results similar to those of uFSH. rFSH enhances steroidogenesis and provokes different androgen/estrogen ratios than does uFSH without influencing the outcome of in votro fertilization.
Deskriptorji		FERTILIZATION IN VITRO OVULATION INDUCTION FSH ESTRADIOL GONADOTROPINS, CHORIONIC ANDROSTENEDIONE TESTOSTERONE FOLLICULAR FLUID OOCYTES SPERMATOZOA EMBRYO TRANSFER PROSPECTIVE STUDIES