Avtor/Urednik		Župunski, Ana
Naslov		Dolgoročno sledenje stenoze renalne arterije transplantirane ledvice
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2002
Obseg		str. 52
Jezik		slo
Abstrakt		BACKGROUND: Renal transplant artery stenosis is a potencially correctable cause of posttransplantation hypertension and/or deterioration of renal function and graft loss. Treatment of stenosis can be medical with antihypertensive drugs or interventional (percutaneous transluminal renal angioplasty (PTRA), surgical revascularisation). With regular Doppler examinations we estimate the progression of stenosis and determine the optimal moment for interventional treatment in an individual patient. Because interventional treatment of stenosis carries a high risk of complications, which can endanger the renal transplant function, we want to avoid unneccessary interventions. PURPOSE: The aim of our retrospective clinical study was to assess the long-term course of renal transplant artery stenosis by duplex Doppler and its influence upon the renal function (serum creatinine), haemoglobin concentration, arterial hypertension and to investigate the connection with the number of posttransplant acute cellular rejection episodes. SUBJECTS AND METHODS: 34 renal transplant recipients, 14 females and 20 males, aged 42.7±13 years, were found to have significant (>50%) renal transplant artery stenosis. Stenoses were diagnosed and followed by duplex Doppler. 23 renal angiographies were performed in 18 patients, 15 PTRAs in 13 patients and 4 surgical interventipns in 3 patients. Stenoses were treated medically in 20/34 patients. In control group there were 34 patients without renal transplant artery stenosis on Doppler, that matched patients from study group for age, sex, time of transplantation, type of renal transplant and number of previous transplantations. RESULTS: In stenosis group average peak systolic velocity (m/s) in renal transplant artery was 2.1±0.5 at 1 year after transplantation (in control group 1.1±0.4) (p<0.001), 1.9±0.5 at 2 years (in control group 0.9±0.4) (p<0.001) and 1.9±0.5 at 3 years (in control group 0.9±0.3) (p<0.001). (Abstract truncated at 2000 characters).
Deskriptorji		KIDNEY TRANSPLANTATION RENAL ARTERY OBSTRUCTION CREATININE HEMOGLOBINS HYPERTENSION ANTIHYPERTENSIVE AGENTS GRAFT REJECTION BIOPSY ULTRASONOGRAPHY, DOPPLER, DUPLEX IMMUNOSUPPRESSIVE AGENTS BLOOD FLOW VELOCITY