Avtor/Urednik		Erman, Andreja; Vidmar, Gaj; Jezernik, Kristijan
Naslov		Temporal and spatial dimensions of postnatal growth of the mouse urinary bladder urothelium
Tip		članek
Vir		Histochem Cell Biol
Vol. in št.		Letnik 121
Leto izdaje		2004
Obseg		str. 63-71
Jezik		eng
Abstrakt		Postnatal growth and renewal of mouse urothelium start on the day of birth. In the present study, temporal and spatial dimensions of urothelial growth were studied during the first two postnatal weeks. Quantitative analysis showed that the rate of urothelial cell proliferation is significantly higher during all 14 postnatal days than in adult mice. Three peaks of proliferative and mitotic activity were revealed: on the day of birth and postnatal day 1, on days 6 and 7, and on day 14. The high proliferation rate around the day of birth and at postnatal davs 6 and 7 coincides with cell death in the urothelium. Semiquantitative analysis showed that during all 14 postnatal days, the urothelial proliferative response is mostly confined to the basal cell layer. Urothelial cells divide predominantly in parallel to the plain of the urothelium on all chosen postnatal days. lncreased portions of urothelial cells, dividing perpendicularly to the urothelium were observed only on the day of birth and on postnatal day 7. Our results suggest that postnatal growth of mouse urothelium is particularly the result of an increasing number of cells in individual cell layers and not the result of an increasing number of cell layers.
Deskriptorji		BLADDER UROTHELIUM CELL DIVISION MITOTIC INDEX TUBULIN MICE, INBRED ICR IMMUNOHISTOCHEMISTRY PROLIFERATING CELL NUCLEAR ANTIGEN KI-67 ANTIGEN