| Avtor/Urednik | Glavin, GB | |
| Naslov | Intramesolimbic dopamine D1 receptor activation reduces stress gastric lesions and gastric acid secretion | |
| Tip | članek | |
| Vir | Exp Clin Gastroenterol | |
| Vol. in št. | Letnik 1, št. 1 | |
| Leto izdaje | 1991 | |
| Obseg | str. 55-60 | |
| Jezik | eng | |
| Abstrakt | We have investigated the role of peripheral and central dopamine (DA) in gastrointestinal disease. We showed previously that pheripherally administred DA1 agonists reduce, while DA1 antagonists worsen, stress- and ethanol-induced gastric lesions. Because of our interest in the brain-gut axis and increasing emphasis on brain regulation of gut function, we examined the role of central DA in experimental gastric lesions and gastric acid secretion. The D1 agonist, SKF38393, was infused into the cell body regions of the nigrostriatal (A9-zona compacta), mesolimbic (A10-vental tegmental area) or the mesocortical (medial A9, A8) DA tracts. Infusion into the mesolimbic DA cell body region and, to a lesser extent, into the nigrostriatal cell body region, were associated with a significant reduction in restraint stress-induced gastric lesions, and basal acid and pepsin output (4 h pylorus-ligated rat). Infusion of the D1 antagonist, SCH23390, into the same regions resulted in a similar pattern, that is, infusion into the mesolimbic area resulted in significant worsening of the stress-induced gastric lesions, with a smaller effect seen with infusion into the nigrostriatal region. SKF38393 infusion into the terminal fields of the major central DA tracts (caudate nucleus, central nucleurs of the amygdala, and medial prefrontal cortex, respectively) again resulted in the same pattern - mesolimbic (amygdalar) application of the agonist reduced gastric lesions, with a smaller effect seen with infusions into the caudate nucleus. These results strongly implicate DA as an endogenous gastroprotective agent which, based upon the present data, appears to exert its effects primarily through both central and peripheral D1/DA1 receptors | |
| Deskriptorji | RECEPTORS, DOPAMINE GASTRIC MUCOSA GASTRIC ACID STRESS LIMBIC SYSTEM DOPAMINERGIC AGENTS CAUDATE NUCELUS SUBSTANTIA NIGRA CORPUS STRIATUM CEREBRAL CORTEX SCH-23390 SK&F-38393 RATS, INBRED STRAINS RATS |