Avtor/Urednik		Sakar, D; Biđin, Z; Prevendar, A
Naslov		Utjecaj vakcinacije protiv gamborske bolesti na aktivnost mikrosomskih monooksigenaza jetre u tovnih pilića
Prevedeni naslov		The effect of vaccination against Gumboro disease on activity of liver microsomal monooxygenases in broiler chicks
Tip		članek
Vir		Vet Arh
Vol. in št.		Letnik 61, št. 1
Leto izdaje		1991
Obseg		str. 1-12
Jezik		cro
Abstrakt		The influence of vaccine against Gumboro disease (Gumbokal, Pliva), which was given to 12-day-old broilers, on the acitivity of two liver microsomal monooxygenases (ethylmorphine N-demethylase and aniline hydroxylase) was examined. It was observed that the tested vaccine markedly depressed the activity of two liver microsomal enzymes in the first 2 days, respectively 5 days after vaccination. The level of enzyme activity was by 60-86 per cent lower in the vaccinated group. The relative liver weight was 10 per cent lower in tested broilers 48 hours after vaccination and slightly raised in the next 3 days (108 per cent). In the first two days after vaccination the weight gain was transitory and slightly depressed. The inhibitory effect of vaccine against Gumboro disease on the microsomal enzyme activity may be a risk for broilers treated with liposoluble drugs of a small therapeutic index, e.g. ionofore antibiotics, which are biotransformed by liver monooxygenases
Deskriptorji		POULTRY DISEASES REOVIRUS INFECTIONS INFECTIOUS BURSAL AGENT MICROSOMES, LIVER OXYGENASES VIRAL VACCINES VACCINES, ATTENUATED ETHYLMORPHINE-N-DEMETHYLASE ANILINE HYDROXYLASE CHICKENS