Avtor/Urednik		Kranjc, Andreja; Peterlin-Mašič, Lucija; Ilaš, Janez; Preželj, Andrej; Stegnar, Mojca; Kikelj, Danijel
Naslov		Novel thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics: optimization via modification of P1 and P3 moieties
Tip		članek
Vir		Bioorg Med Chem Lett
Vol. in št.		Letnik 14, št. 12
Leto izdaje		2004
Obseg		str. 3251-6
Jezik		eng
Abstrakt		Optimization of lead compounds 1 and 2 resulted in novel, selective, and potent thrombin inhibitors incorporating weakly basic heterobicyclic Pl-arginine mimetics. The design, synthesis, and biological activity of racemic thrombin inhibitors 17-29 and enantiomerically pure thrombin inhibitors 30-33 are described. The arginine side-chain mimetics used in this study are 4,5,6,7tetrahydro-l,3-benzothiazol-2-amine, 4,5,6,7-tetrahydro-2H-indazole, and 2-imino-4,5,6,7-tetrahydro-l,3-benzothiazol-3(2H)-ylamine.
Deskriptorji		THROMBIN ANTICOAGULANTS PYRIDONES ACETAMIDES ARGININE STEREOISOMERISM THROMBIN TIME PROTHROMBIN TIME PARTIAL THROMBOPLASTIN TIME TRYPSIN