Avtor/Urednik		Dabić-Jeftić, M; Drakulić, V; Lang, B
Naslov		Long latency event related potentials (P 300) in the evaluation of cognitive function in alcoholics
Tip		članek
Vir		Alcoholism
Vol. in št.		Letnik 27, št. 1-2
Leto izdaje		1991
Obseg		str. 9-16
Jezik		eng
Abstrakt		In the present study we investigated P300 latency differences in 40 alcoholics with and without cognitive disorders that were either functional or organically based, as determined by neuropsychological testing. The same investigation was done in nonalcoholics as a control group. Auditory P300 recordings were made at Fz Cz and Pz reference to linked mastoids. An Fp2 electrode was used to monitor blinks and other electro-oculographics artefacts. Stimulus detection paradigm was employed within run consisting of 400 tone pips. Frequent expected (1000 Hz) and rare unexpected (3000 Hz) tones were delivered at random. Evoked potentials were averaged with a Medilog system - Apple computer. Patients were instructed to count the number of rare tones, but if the patient was incapable of counting, he was instructed to give a hand siglan to observers when a rare tone was detected. The sequence was repeated at least once to establish test-retest reliability. The evoked potentials waveforms were averaged separately to rare frequent tones. Peak latency to the P300 component to the rare tone was derived by using the point of intersection of "best-fit slope line on either side of the component peak. Cognitive and neurological status was assessed by a psychologist or a psychiatrist (without knowledge of P300 results). The results of the study P300 latency differences appear to exist between alcholics with and without cognitive disorders but they are not statistically significant. The significant difference of mean P300 latency is found between alcoholics and controls at the level of P=0.01 at Fz electrode position and at the level of p=0.05 at Cz and Pz electrode position. The alcoholics' ERP-s are similar to unexpected and expected inputs both in terms of amplitude and latency measures. These findings suggest impaired sensory filtering and probably matching process, in both alcoholic groups - without and with cognitive disorders
Deskriptorji		ALCOHOLISM COGNITION DISORDERS EVOKED POTENTIALS, AUDITORY REACTION TIME BRAIN ADULT MIDDLE AGE