Avtor/Urednik		Gradišnik, Peter
Naslov		Procjena rizika za pojavu epilepsije u nedonošenčadi s perinatalnim oštećenjem mozga
Tip		monografija
Kraj izdaje		Zagreb
Založnik		Sveučilište u Zagrebu, Medicinski fakultet
Leto izdaje		2004
Obseg		str. 106
Jezik		cro
Abstrakt		Epilepsy is the frequent outcome of perinatal brain damage with term newborns. Studies looking at neurological outcome with prematurely born children are mainly oriented towards evaluation of motor development. It is now accepted that damage to brain-tissue partly occurs due to prenatal pathological events. It is the concluding process of brain cortex formation going on during the final trimester of pregnancy that opens possibility of secondary development of cortical brain damage following the primary exposure of white matter. The present research was aimed at establishing whether antenatal developed periventricular damage to brain-tissue with premature babies can cause in early age onsets of epilepsy or of abnormally altered bioelectrical activity as a subclinical pointer of enlarged risk for the onset of epilepsy later on. The research included 91 prematures born during years 1992-1994 in the Maribor Maternity Ward who underwent brain ultrasound during the first week and 14 children currently treated in the Zagreb Children's Clinic. On the basis of the medical documentation we retrogradly categorised their ultrasound readings according to the degree of brain damage and the approximate time of the occurence of the damage. The children were neurologically examined and their motor development was evaluated. Their electroencephalogram recordings and assembled data regarding the eventual occurence of epilepsy were classified. The potential prognostic factors were compared with the incidence of overt epilepsy or with abnormally altered bioelectrical brain activity. Using the binary logistic regression method, the relative risk of the occurence was established for each of the potential factors. 48.6% of the children had a completely normal brain ultrasound. Instances of brain-tissue damage were localised in periventricular white matter. Non of the children had cortical damage ascertainable by ultrasound. (Abstract truncated at 2000 characters).
Deskriptorji		INFANT, PREMATURE LEUKOMALACIA, PERIVENTRICULAR CEREBRAL HEMORRHAGE EPILEPSY ELECTROENCEPHALOGRAPHY NEUROLOGIC EXAMINATION INFANT, NEWBORN