| Avtor/Urednik | Skalerič, Eva | |
| Naslov | Raven nekaterih kazalcev vnetja in inflamatornih citokinov v serumu bolnikov s parodontalno boleznijo | |
| Prevedeni naslov | The levels of some inflammatory mediators and cytokines in the sera of patients with periodontal disease | |
| Tip | članek | |
| Vir | Med Razgl | |
| Vol. in št. | Letnik 43, št. 1 | |
| Leto izdaje | 2004 | |
| Obseg | str. 1-17 | |
| Jezik | slo | |
| Abstrakt | Periodontal disease is the most widespread disease of all chronic inflammatory diseases. The initiation and development of inflammation in the periodontal tissue is influenced by the number and type of microorganisms and by the inflammatory immune host response. Analytical epidemiology and molecular biology studies in the last decade have shown that periodontal inflammation does not only present a risk for tooth loss, but may also play a role in the development of certain systemic diseases. Periodontal disease plays a role in development of some diseases via direct penetration of microorganisms into the bloodstream through an ulcerated inner gingival epithelium and by increasing the levels of some inflammatory mediators and cytokines in the serum. The aim of our study was to determine the levels of inflammatory mediators (C-reactive protein (CRP), fibrinogen, procalcitonin) and inflammatory cytokines (IL-2, sIL-2R, IL-6, IL-8, TNF-a) in the serum of systemically healthy blood donors with periodontal disease. Our hypothesis was that the size of soft periodontal pocket wall in contact with bacteria (infected periodontal wound) influences the level of inflammatory mediators and cytokines in the serum. For the evaluation of infected periodontal wounds, the cervical circumference was measured at the cemento-enamel junction on 515 extracted teeth. The average values of cervical circumferences of individual teeth were multiplied by the average values of six measurements of probing depth for individual teeth in 31 blood donors. The sum of all products for individual teeth presented the size of the infected periodontal wound for each individual. The sum of all products of periodontal pocket measurements, which bled on probing, presented the size of the active infected periodontal wound. (Abstract truncated at 2000 characters) | |
| Izvleček | Parodontalna bolezen je najbolj razširjena kronična vnetna bolezen ljudi. Začetek in razvoj vnetja obzobnih tkiv je pogojen s številom in vrsto mikroorganizmov v plaku ter z vnetno imunološkim odgovorom organizma. Raziskave s pomočjo analitične epidemiologije in molekularne biologije v zadnjem desetletju so pokazale, da vnetni proces v obzobnih tkivih ne ogroža samo obstoja zob, ampak lahko doprinese tudi k razvoju nekaterih sistemskih bolezni. Parodontalna bolezen sodeluje pri razvoju nekaterih bolezni z neposrednim vdorom mikroorganizmov preko ulceriranega notranjega gingivalnega epitelija v krvotok ter s porastom nekaterih mediatorjev vnetja in inflamatornih citokinov v krvi. Namen raziskave je bil pri sistemsko zdravih krvodajalcih s parodontalno boleznijo ugotoviti koncentracijo kazalcev vnetja (C-reaktivni protein (CRP), fibrinogen, prokalcitonin) in inflamatornih citokinov (IL-2, sIL-2R, IL-6, IL-8, TNF-a) v njihovem serumu. Previdevali smo, da velikost mehke stene obzobnih žepov v stiku z bakterijami (okužena parodontalna rana) vpliva na koncentracijo vnetnih mediatorjev in citokinov v serumu. Za oceno okužene parodontalne rane smo izmerili obseg zobnega vratu na 515 ekstrahiranih zobeh. Povprečne vrednosti obsega zobnega vratu posameznega zoba smo zmnožili s povprečno vrednostjo šestih meritev globine sondiranja posameznega zoba pri preiskovanih osebah. Vsota zmnožkov vrednosti posameznih zob je predstavljala velikost okužene parodontalne rane posameznega bolnika. Vsota zmnožkov meritev globine obzobnih žepov, ki so krvaveli ob sondiranju, pa je predstavljala velikost aktivne okužene parodontalne rane. V raziskavo smo vključili 31 sistemsko zdravih moških krvodajalcev, starih od 30 do 56 let (povprečno 43,2 leti). Naš parodontalni pregled je vključeval meritve globine obzobnih žepov in prisotnost krvavitve ob sondiranju. (Izvleček skrajšan pri 2000 znakih) | |
| Deskriptorji | PERIODONTAL DISEASES INFLAMMATION MEDIATORS CYTOKINES TOOTH CERVIX PERIODONTAL POCKET ADULT MIDDLE AGE C-REACTIVE PROTEIN FIBRINOGEN CALCITONIN INTERLEUKIN-2 RECEPTORS, INTERLEUKIN-2 INTERLEUKIN-6 INTERLEUKIN-8 TUMOR NECROSIS FACTOR PERIODONTAL INDEX |