Avtor/Urednik		Božič, Mojca; Furlan, Danijela; Stegnar, Mojca
Naslov		D-dimer pri izključevanju venske tromboze - katero metodo uporabiti?
Prevedeni naslov		D-dimer in exclusion of deep-vein thrombosis - which method?
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 55
Leto izdaje		2004
Obseg		str. 221-5
Jezik		slo
Abstrakt		In Slovenia D-dimer concentration is being determined in practically all general hospital laboratories, mostly as an aid in exclusion of deep-vein thrombosis (VT). The method development started with enzyme-linked immunosorbent assay (EL1SA), followed by quick agglutination methods and finally automated immunoturbidimetric methods. The latter have not yet been fully evaluated in clinical studies. The aim of our study was to asses diagnostic performance of D-dimer determined with three different immunoturbidimetric methods. We found good diagnostic characteristics for method A (sensitivity 100% and specificity 59%) and method C (sensitivity 100% and specificity 60%) that were comparable to the reference method (sensitivity 100% and specificity 73%). Although D-dimer determined with method B reliably excluded VT (sensitivity 100% and specificity 22%), it only in small degree attributed to VT diagnosis, since D-dimer was elevated also in the majority of patients without VT.
Izvleček		Koncentracijo D-dimera merimo v Sloveniji praktično v vseh laboratorijih splošnih bolnišnic, najpogosteje kot pomoč pri izključevanju venske tromboze (VT). Razvoj metod za merjenje koncentracije D-dimera je šel od encimskih imunoadsorpcijskih metod (ELISA) preko hitrih aglutinacijskih do avtomatiziranih imunoturbidimetričnih metod. Slednje pa še niso bile v zadostni meri preizkušene v kliničnih raziskavah. V naši raziskavi smo proučili diagnostično uporabnost D-dimera izmerjenega s tremi imunoturbidimetričnimi metodami. Ugotovili smo, da ima merjenje koncentracije D-dimera z metodama A (občutljivost 100% in specifičnost 59%) in C (občutljivost 100% in specifičnost 60%) dobro diagnostično uporabnost, ki je primerljiva z referenčno metodo (občutljivost 100% in specifičnost 73%). Čeprav je nizka koncentracija D-dimera, izmerjena z metodo B, zanesljivo izključila VT (občutljivost 100% in specifičnost 22%), je v majhni meri pripomogla k prepoznavanju VT, saj je bila povišana tudi pri večini bolnikov, ki VT niso imeli.
Deskriptorji		THROMBOPHLEBITIS DIMERIZATION ENZYME-LINKED IMMUNOSORBENT ASSAY NEPHELOMETRY AND TURBIDIMETRY SENSITIVITY AND SPECIFICITY