Avtor/Urednik     Rozman, Janez; Bunc, Matjaž
Naslov     Modulation of visceral function by selective stimulation of the left vagus nerve in dogs
Tip     članek
Vir     Exp Physiol
Vol. in št.     Letnik 89, št. 6
Leto izdaje     2004
Obseg     str. 717-25
Jezik     eng
Abstrakt     The superficial regions of the left vagus nerves of a dog were selectively stimulated with 39-electrode spiral cuffs having thirteen circumferential groups of three electrodes (GTE) to modulate the function of the innervated internal organs and glands. Under general anaesthesia, the cuffs were chronically implanted on the nerve at the neck in two adult Beagle dogs and remained viable for 16 months. The regions were stimulated with biphasic, rectangular and current pulses (2 mA, 200 micro s, 20 Hz) delivered to the group of GTE being close to the region innervating the specific internal organs or glands. The results showed that specific electrode configurations had actions on the heart (GTE 9), lungs (GTE 4) and pressure in the urinary bladder (GTE 1). It was also shown that GTE no. 10 significantly modified the endocrine function of the pancreas. Results of this study clearly demonstrate that internal organs and glands can be selectively stimulated via the selective stimulation of innervating superficial regions of the autonomous peripheral nerve.
Deskriptorji     VAGUS NERVE
ELECTRIC STIMULATION
HEART RATE
GLUCAGON
INSULIN
DOGS
C-PEPTIDE
BLOOD PRESSURE
ELECTROCARDIOGRAPHY
RESPIRATION
BLADDER
ELECTRODES, IMPLANTED
RADIOIMMUNOASSAY