| Avtor/Urednik | Samarin-Lovrič, Silvia; Avbelj, Viktor; Trobec, Roman; Zorman, Darko; Rakovec, Peter; Hojker, Sergej; Geršak, Borut; Milčinski, Metka | |
| Naslov | Sympathetic reinnervation after heart transplantation, assessed by iodine-123 metaiodobenzylguanidine imaging, and heart rate variability | |
| Tip | članek | |
| Vir | Eur J Cardiothorac Surg | |
| Vol. in št. | Letnik 26 | |
| Leto izdaje | 2004 | |
| Obseg | str. 736-41 | |
| Jezik | eng | |
| Abstrakt | Objective: Complete allograft denervation occurs during heart transplantation. Partial ventricular sympathetic reinnervation may develop one year or later after transplantation and can be measured with iodine-l23-meta-iodobenziylguanidine (MIBG) uptake. Aim of this sfudy was to assess sinus node sympathetic reinnervation measured with heart rate variability and ventricular sympathetic reinnervation evaluated with MIBG. Methods: Twelve patients and 14 healthy controls were included. In patients, MIBG scintigraphy with early and late imaging was performed. Heart to mediastinum ratio (HMR) was calculated and patients were divided in groups with (HMR> 1.3) and without left ventricular reinnervation (HMR < 1.3). Bipolar ECG with high sampling rate and resolution was recorded over 8.5 min in supine position and in upright position after 10 min interval. R-R intervals in time domain and heart rate variability in frequency domain through spgctral power analysis of R-R intervals were analysed to evaluate sinus node reinnervation. Spectral power in low frequency range (0.04-0.IS Hz) above 4.5 ms2 was considered as sinus node sympathetic reinnervation. Results: Six (50%) patients had evidence of left ventricular sympathetic reinnervation on scintigraphy. Sinus node sympathetic reinnervation based on heart rate variability was detected in 6 (50%) patients in supine, and in 4 (33%) patients in upright body position. Four patients groups were discerned: (1) with ventricular and sinus node sympathetic reinnervation, (2) with sinus node sympathetic reinnervation, (3) with ventricular sympathetic reinnervation and (4) without atrial or venlricular sympathetic reinnervation. Ventricular reinnervation process was time dependent and sinus node reinnerva(ion was not. (Abstracts truncated at 2000 characters) | |
| Deskriptorji | HEART TRANSPLANTATION HEART SYMPATHETIC NERVOUS SYSTEM IODINE RADIOISOTOPES BENZYL COMPOUNDS GUANIDINES HEART RATE ELECTROCARDIOGRAPHY SUPINE POSITION |