Avtor/Urednik		Koren, Srečko
Naslov		Onkogeni mehanizmi tumorskih virusov
Prevedeni naslov		Oncogenic mechanisms of tumor viruses
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 43, št. Suppl 5
Leto izdaje		2004
Obseg		str. 131-8
Jezik		slo
Abstrakt		The study of RNA and DNA tumor viruses has revealed major basic concepts of cancer development, including the functions of cellular oncogenes, tumor suppressor genes and viral oncogenes. It is now well established that different viruses belonging to retroviruses, papillomaviruses, herpesviruses, hepadnaviruses and flaviviruses have an important role in the etiology of human cancer. This brief review describes the molecular and cellular mechanisms underlying viral carcinogenesis. Also the oncogenic potential of the best-studied human tumor viruses, such as human T-cell leukaemia/lymphoma virus type 1, human papillomaviruses, Epstein-Barr virus, human herpesvirus 8, hepatitis B virus and hepatitis C virus is discussed in detail.
Izvleček		Proučevanje tumorskih virusov z RNK in DNK je odkrilo glavne temeljne koncepte razvoja raka, vključujoč delovanje celičnih onkogenov in tumorje zavirajočih genov ter virusnih onkogenov. Danes je splošno sprejeto dejstvo, da imajo različni virusi, uvrščeni v retroviruse, papilomaviruse, herpesviruse, hepadnaviruse in flaviviruse pomembno vlogo v etiologiji rakavih bolezni pri človeku. Kratek pregledni članek opisuje molekularne in celične mehanizme virusne karcinogeneze. Prav tako je podrobno prikazana onkogena zmožnost najbolje proučenih človeških tumorskih virusov: človeškega virusa levkemije/limfoma celic T tipa 1, papilomavirusov, virusa Epstein-Barr, človeškega herpesvirusa 8, virusa hepatitisa B in virusa hepatitisa C.
Deskriptorji		NEOPLASMS ONCOGENIC VIRUSES ONCOGENE PROTEINS, VIRAL HEPATITIS B VIRUS RETROVIRIDAE PROTEINS, ONCOGENIC PAPILLOMAVIRUS, HUMAN HERPESVIRIDAE INFECTIONS HERPESVIRUS 4, HUMAN