Avtor/Urednik		Škoberne, Mojca
Naslov		Apoptotične celice in vpliv na imunski odziv
Prevedeni naslov		Immunomodulatory role of apoptitic cells
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 43, št. Suppl 5
Leto izdaje		2004
Obseg		str. 173-6
Jezik		slo
Abstrakt		Over the past few years, evidence has accumulated indicating that clearance of apoptotic cells by phagocytes such as macrophages and dendritic cells can result in anti-inflammatory and immunosuppressive effects. Uptake of apoptotic cells by phagocytes involves several receptors and several among them have been implied to mediate inhibitory effects on dendritic cell maturation and to lead to potentially tolerogenic signals. We speculate that only discrete receptor ligation will modulate the outcome of apoptotic cell uptake at the phagocyte level and the resulting stimulation of effector T cells.
Izvleček		Fagocitne celice, predvsem makrofagi in dendritične celice, učinkovito odstranjujejo apoptotsko umirajoče celice. Stik med fagociti in apoptotičnimi celicami lahko sproži prorivnetni odziv, ima zavirajoče učinke na razvoj imunosti in sodeluje pri vzdrževanju tolerance do lastnih antigenov. Pri fagocitozi apoptotičnih celic sodeluje veliko receptorjev, vendar domnevamo, da le nekateri od njih prispevajo k zaviranju zorenja dendritičnih celic in posledično k spremenjenemu odzivu limfocitov T.
Deskriptorji		DENDRITIC CELLS PHAGOCYTES APOPTOSIS ADJUVANTS, IMMUNOLOGIC BIOTIN