Avtor/Urednik		Zaletel, Marjan
Naslov		Študija živčnožilne sklopitve z vidnimi evociranimi potenciali in dopplersko sonografijo
Prevedeni naslov		The study of neurovascular coupling by visual evoked potentials and Doppler sonography
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2004
Obseg		str. 121
Jezik		slo
Abstrakt		Introduction: Neuronal activity, cerebral metabolism and regional cerebral blood flow are tightly coupled. The term neurovascular coupling denotes the relationship between neuronal activity and regional cerebral blood flow. It enables the maintenance of regional cerebral blood flow as well as its adaptation to regional neuronal activity and metabolism; it is thus essential for the normal functioning of the brain. The mechanism of neurovascular coupling is not clear. It is also not known whether it is altered in neurologic diseases such as migraine. A method that would enable analysis of neurovascular coupling in humans, is still to be discovered. The analysis would require a change of neuronal activity, and a noninvasive simultaneous monitoring of regional blood flow and neuronal activity. Neuronal activity could be noninvasively recorded by measuring visually evoked potentials (VEP), changed by applying different visual contrasts. At the same time, regional blood flow could be monitored by using transcranial Doppler (TCD) and analyzing visually evoked cerebral blood flow responses (VEFR). The aim of our study was to establish whether visual contrast affects VEFR, whether VEFR relate to VEP, and whether the relationship between VEP and VEFR is interictally altered in patients with migraine. Subjects and Methods: The records were made from 30 healthy volunteers of both sexes (8 men and 22 women), aged 38.0 ± 9.6 years, and 30 patients with migraine (10 men and 20 women), aged 36.6 ± 10.4 years. 16 patients had migraine without aura (MwA) and 14 had migraine with aura (MA). The neurologic clinical examination as well as the general physical status were normal in all the subjects. The angiosonography of precerebral vessels did not show any pathologic changes. (Abstract truncated at 2000 characters).
Deskriptorji		MIGRAINE CEREBROVASCULAR CIRCULATION CEREBRAL ANGIOGRAPHY EVOKED POTENTIALS, VISUAL ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL BLOOD FLOW VELOCITY CAPNOGRAPHY BLOOD PRESSURE HEART RATE