Avtor/Urednik		Vrtovec, Bojan; Šinkovec, Matjaž; Starc, Vito; Radovančević, Branislav; Schlegel, Todd T
Naslov		Coronary artery disease alters ventricular repolarization dynamics in type 2 diabetes
Tip		članek
Vir		Pacing Clin Electrophysiol
Vol. in št.		Letnik 28, št. Suppl 1
Leto izdaje		2005
Obseg		str. S178-S81
Jezik		eng
Abstrakt		Ventricular repolarization dynamics (VRD) is an important predictor of outcome in diabetes. We examined the potential impact of coronary artery disease (CAD) on VRD in type 2 diabetic patients. We recorded 5-minute high-resolution resting electrocardiograms in 38 diabetic patients undergoing elective coronary angiography, and in 38 age- and gender-matched apparently healthy subjects (controls). Using leads-1 and -11, time-domain indices of VRD were calculated. Coronary angiography was regarded as positive if >= 50% stenosis was found. Angiography was positive in 21 diabetic patients (55%). Patients with CAD had a significantly higher degree of VRD than controls (SDNN(QT): 15.81 +- 7.22 ms versus 8.94 +- 6.04 ms; P < 0.001, rMSSD((ZT): 21.02 +- 7.07 ms versus 11.18 +- 7.45 ms; P < 0.001). Ventricular repolarization dynamics in diabetic patients with negative angiograms did not differ from VRD in controls (SDNN(QZT): 8.94 +- 6.04 ms versus 7.44 +- 5.72 ms; P = 0.67, rMSSD(QT): 11.18 +- 7.45 ms versus 10.22 +- 5.35 ms; P = 0.82). CAD increases VRD in patients with type 2 diabetes. Therefore, changes in ventricular repolarization in diabetic patients may be due to silent CAD rather than due to diabetes per se.
Deskriptorji		DIABETES MELLITUS, NON-INSULIN-DEPENDENT CORONARY DISEASE HEART RATE DIAGNOSIS, COMPUTER-ASSISTED ELECTROCARDIOGRAPHY CORONARY ANGIOGRAPHY HEART CATHETERIZATION MYOCARDIAL CONTRACTION CASE-CONTROL STUDIES