Avtor/Urednik     Miš, Katarina
Naslov     Izražanje živčnomišičnih komponent v hrbtenjači sesalca
Prevedeni naslov     Expression of the neuromuscular components in the mammalian spinal cord
Tip     monografija
Kraj izdaje     Ljubljana
Založnik     Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje     2004
Obseg     str. 114
Jezik     slo
Abstrakt     Introduction and aim: Communication between neurons is the essence of the function of the nervous system. Structures that enable specific, spatially and temporally limited transfer of information either between neurons, or from neurons to the other target cells, like skeletal muscle fibers, are synapses. Various modulations of interneuronal communications, which are the basis of higher functions of the central nervous system (CNS) like learning and memory, are also exerted primarily at the synaptic level. In spite of morphological and neurochemical variety of synapses, virtually all of our current understanding of synaptic development and function derives from the studies on only one synapse, the neuromuscular junction (NMJ). Due to its experimental accessibility, this synapse is still in many aspects considered a model synapse. The basic features of the mechanisms underlying transfer of action potential across the synaptic cleft of the NMJ have already been elucidated. However, the mechanisms underlying formation and differentiation of the NMJ, which are also the basis of the synaptic plasticity are still mostly unknown and are extensively investigated. One experimental approach to study these mechanisms is to follow spatial and temporal patterns of expression of synaptic components and their targeting at various stages of the NMJ formation. Part of these mechanisms are taking place at the spinal cord level, more precisely in the alpha-motor neuron. Namely, several aspects of the NMJ formation are controlled by the factors released from the alpha-motor neuron, which by itself contributes a series of molecular component that constitute the NMJ. It has been generally accepted, that nerve-derived agrin controls the aggregation of synaptic components in the NMJ. Another essential NMJ component, which is also known to be at least partly contributed by the alpha-motor neuron is acetylcholinesterase (AChE). (Abstract truncated at 2000 characters)
Deskriptorji     BUTYRYLCHOLINESTERASE
AGRIN
SPINAL CORD
NEUROMUSCULAR JUNCTION
ACETYLCHOLINESTERASE
RNA, MESSENGER
MOTOR NEURONS
IN SITU HYBRIDIZATION
POLYMERASE CHAIN REACTION
RNA PROBES
DIGOXIGENIN
RATS, WISTAR