Avtor/Urednik		Bevc, Sebastjan; Hojs, Radovan; Ekart, Robert
Naslov		Sekundarna amiloidoza ob kronični vnetni bolezni črevesja ter nefrotični sindrom
Prevedeni naslov		Secondary amyloidosis with inflammatory bowel disease and nephrotic syndrom
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 43, št. 4
Leto izdaje		2004
Obseg		str. 403-9
Jezik		slo
Abstrakt		Amyloidosis is a group of diseases for which extracellular deposition of a fibrillary protein called amyloid is typical. There are many types of amyloidoses. Secondary amyloidosis is connected with pre-existing inflammatory disorders, which also include inflammatory bowel disease. The kidneys are important target organs, which explains the fact that proteinuria is usually the first sign of amyloid deposition in the kidneys. Nephrotic syndrome is important for prognosis of this disease. The diagnosis of secondary amyloidosis requires pathohistochemical and immunohistochemical tests.'fhe treatment of seeondary amyloidosis is limited to colchicin therapy and healing of the underlying inflammatory process and its complications. The authors presented a rare disease, secondary amyloidosis with nephrotic syndrome associated with inflammatory bowel disease.
Izvleček		Amiloidoza je raznovrstna skupina bolezni, za katero je značilno izvencelično odlaganje kompleksne beljakovinske strukture, imenovane amiloid. Poznamo več vrst amiloidoz. Sekundarna amiloidoza ali AA amiloidoza je povezana s predhodnimi vnetnimi procesi, med katcre sodi tudi kronična vnetna bolezen črevesja. Za bolezenski proces so ledvice pomemben tarčni organ. Proteinurija je največkrat prvi znak nalaganja amiloida v ledvicah, nefrotični sindrom pa je pomemben za napoved izida bolezni. Za postavitev diagnoze je potrebna patohistološka in imunofluorescenčna analiza ledvične biopsije. Zdravljenje AA amiloidoze je omejeno na kolhicin in zdravljenje osnovnega vnetnega procesa ter njegovih zapletov. Avtorji predstavljajo redko bolezen, AA amiloidozo z nefrotičnim sindromom v povezavi s kronično vnetno boleznijo črevesja.
Deskriptorji		INFLAMMATORY BOWEL DISEASES NEPHROTIC SYNDROME AMYLOIDOSIS PROTEINURIA