Avtor/Urednik     Petrovič, Daniel; Peterlin, Borut
Naslov     Genetic markers of restenosis after coronary angioplasty and after stent implantation
Tip     članek
Vir     Medical science monitor
Vol. in št.     Letnik 11, št. 4
Leto izdaje     2005
Obseg     str. 127-35
Jezik     eng
Abstrakt     Apart from coronary artery bypass grafting, percutaneous transluminal coronaryangioplasty (PTGA) and intracoronary stent placement are well established treatment strategies for CAD. Substantial differences exist in the mechanisms of restenosis between conventional PTCA and stenting. Arterial remodeling is the main contributor to lumen re-narrowing after PTCA, whereas neointimal hyperplasia is almost the sole mechanism of restenosis after stenting. Several reports have demonstrated that genetic factors may be involved in the pathogenesis of restenosis after PTCA and in-stent restenosis. In this review the candidate genes involved in the pathogenesis of restenosis are analyzed as potential genetic markers of restenosis after PTCA and in-stent restenosis. The I/D angiotensin-I converting enzyme gene polymorphism, gene polymorphisms of the endothelial nitric oxide synthase (G1u298Asp, -786T>C), the glycoprotein IIIa P1A1/A2 gene polymorphism, gene polymorphism of the estrogen (PvuII), allele 2 of the interleukin-lra gene, and the GT repeats in heme oxygenase-1 gene promoter may be used as genetic markers for in-stent-restenosis. On the other hand, only the stromelysin-1 5A/6A gene polymorphism and allele 2 of the interleukin -lra gene may be used as a genetic marker for restenosis after PTCA.
Deskriptorji     ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY
STENTS
CORONARY DISEASE
RECURRENCE
GENETIC MARKERS
POLYMORPHISM (GENETICS)
ANGIOTENSINS
NITRIC-OXIDE SYNTHASE
CYTOKINES
BLOOD COAGULATION FACTORS
SEX HORMONES