Avtor/Urednik		Praprotnik, Marina
Naslov		Učinek antagonistov levkotrienskih receptorjev na potek bronhiolitisa pri otrocih
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2004
Obseg		str. 54
Jezik		slo
Abstrakt		Bronchiolitis is the most common lower respiratory tract infection in the first two years of life. It is most commonly associated with viruses especially with respiratory syncytial virus. While significant number of studies regarding treatment of RSV bronchiolitis have been made in the past years, there continues to be a fair amount of controversy about the optimum management of infants and children with RSV infection. Many observations provide evidence for the release of leukotrienes in the nasopharynx of children during viral respiratory illness. Leukotriene receptor antagonists are currently used in the treatment of asthma and allergic rhinitis. By our knowledge no studies have been performed with leukotriene receptor antagonists in early phase of acute bronchiolitis till now. Their effect on clinical course of acute bronchiolitis is still obscure. We hypothesized that leukotriene receptor antagonists might ameliorate inflammation subsequent to release of leukotrienes in RSV bronchiolitis. We aimed to show the effect of montelukast on a clinical course of acute bronchiolitis in infants when compared to placebo. We conducted a randomised, double-blind, placebo-controlled trial comparing montelukast with placebo in 42 children aged 6 to 24 months who were admitted to Pediatric clinic in Ljubljana with a clinical diagnosis of bronchiolitis. The primary outcome measures were respiratory clinical status which was assessed using the Respiratory Distress Assessment Instrument (RDAI), respiratory rate, heart rate and arterial oxygen saturation (SpO2). There was no significant difference in RDAI, respiratory rate, heart rate and SpO2 in the group treated with montelukast when compared to placebo. Montelukast therapy did not affect the duration of hospitalisation neither the need for the supplemental oxygen. Conclusion: in our study montelukast did not significamtly affect the clinical course of acute bronchiolitis in children when compared to placebo.
Deskriptorji		BRONCHIOLITIS RECEPTORS, LEUKOTRIENE HOSPITALIZATION INFANT TREATMENT OUTCOME RANDOMIZED CONTROLLED TRIALS DOUBLE-BLIND METHOD