Avtor/Urednik		Prodnik, Luka; Sever, Nejc
Naslov		Korelacija med rezultatom klasične citologije in kvantitativne citometrije induciranega izkašljaja in brisa bukalne sluznice pri bolnikih s pljučnim rakom in bolnikih z dejavniki tveganja
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2004
Obseg		str. 45
Jezik		slo
Abstrakt		BACKGROUND. Lung cancer is the most common cause for cancer related deaths both in the world and Slovenia. Its incidence has been increasing and in 1998 lung cancer counted 79% of all cancers in Slovenia. Approximately 85% patients with lung cancer die of it. In the last 25 years lung cancer survival has not improved. The early detection of lung cancer is the most important for a successful treatment survival of lung cancer patiets is over 75% if the tumor is discovered in the stage 1 (which is rarely). Screening with combination of chest radiography and sputum citology has proved unsuccessful, due to low specifity of radiography and low sensitivity of citology. Computer tomography (CT) has a very high sensitivity but low specificity which gives a large number of false positive results. Automated quantitative cytometry (AQC) relies on measuring multiple features of nuclei in the visibly healthy cells of a sample which are taken together as a numerical value point of the probability of the presence of lung cancer in a paticnt. AIM. The aim of our study was to compare conventional sputum cytology, sputum AQC, and buccal mucosa AQC as a screening test in early lung cancer detection with emphasis on the mutual dependence of the methods. We also tried to improve the accurancy of AQC test by combining sputum AQC and buccal mucosa AQC. HYPOTHES IS. Sputum AQC is a more reliable method than conventional sputum cytology and buccal mucosa AQC. When the results of the combined sputum and buccal mucosa AQC are congruous, they are more reliable than sputum AQC alone. (Abstract truncated at 2000 characters).
Deskriptorji		LUNG NEOPLASMS SPUTUM MOUTH MUCOSA IMAGE CYTOMETRY NEOPLASM STAGING ROC CURVE