Avtor/Urednik		Benca, Maja
Naslov		Pomen homocisteina pri potomcih oseb s klinično manifestno aterosklerozo
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2004
Obseg		str. 53
Jezik		slo
Abstrakt		BACKGROUND Elevated plasma total homocysteine is an independent risk factor for cardiovascular diseases (CVD). This amino acid is a true metabolic intermediary product. Once derived from methionine, is has to be "degraded" into cysteine or »regenerated« back to methionine. If these reactions are in any way inhibited or slowed down (for genetic defects, lifestyle factors or deficiencies of vitamins crucial to its metabolism), raised blood concentralion of homocysteine (HCY) seems to become very harmful to our body, causing vaseular damage, among other things. Possible mechanisms for homocysteine's atherogenic and thrombogenic effects are still under investigation, but the promissing one seems to be its noxious effect on endothelial function. AIM The aim of our study was to compare young adults, whose parents had sufferred some sort of a premature cardiovascular event with those whose parents were "healthy". In order to evaluate the irnpact of HCY on their cardiovascular system, we determined HCY in all the participants and measured their carotid artery intima-media thickness (IMT). They also underwent ambulatory blood pressure (BP) and heart rate (HR) monitoring. HYPOTHESIS I. Total plasma homocysteine concentration is higher in young adults whose parents have experienced a premature cardiovascular event. II. Higher HCY is associated with a) a higher 24h-blood pressure, b) a higher 24h-heart rate and c) larger carotid intima-media thickness. METHODS In this case-controlled cross-sectional study a sample of 30 young adults (age (18-31) with a positive parental history of premature CVD and 30 "healthy" controls (same age and gender) was evaluated for HCY (fluorescence polarization imnumoassay), ultrasound-determined carotid IMT and ambulatory BP monitoring results. (Abstract truncated at 2000 characters).
Deskriptorji		ATHEROSCLEROSIS HOMOCYSTEINE CAROTID ARTERIES TUNICA INTIMA TUNICA MEDIA BLOOD PRESSURE MONITORING, AMBULATORY HEART RATE