Avtor/Urednik		Puizina-Ivić, N; Bezić, J; Marasović, D; Gotovac, V; Čarija, A; Božić, M
Naslov		Angiosarcoma arising in sclerodermatous skin
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 14, št. 1
Leto izdaje		2005
Obseg		str. 20-5
Jezik		eng
Abstrakt		We report a case of cutaneous angiosarcoma in a 77-year-old female patient with systemic sclerosis. The tumor developed around a large telangiectasia in the left temporal region. Later on, extensive asymptomatic redness and edema with several nodules over the whole left side of the face developed. Since the conservative therapy failed to produce any improvement, a diagnostic skin biopsy was performed. The pathohistological diagnosis was moderately differentiated angiosarcoma. The patient was treated with a combination of chemotherapy and electron beam irradiation. Despite a notable cutaneous improvement, the control check-up revealed the presence of metastases of the lung and liver. This is the first report of cutaneous angiosarcoma occuring in sclerodermatous skin. The possible pathogenesis of this rare tumorogenic transformation of soft tissues is discussed.
Deskriptorji		SCLERODERMA, SYSTEMIC HEMANGIOSARCOMA TELANGIECTASIS NEOPLASM METASTASIS AGED