Avtor/Urednik		Strojnik, Tadej; Lah, Tamara T; Židanik, Boris
Naslov		Immunohistochemical staining of cathepsins B, L and stefin A in human hypophysis and pituitary adenomas
Tip		članek
Vir		Anticancer Res
Vol. in št.		Letnik 25, št. 1B
Leto izdaje		2005
Obseg		str. 587-94
Jezik		eng
Abstrakt		Background: New biological markers are needed for diagnosis of atypical pituitary adenoma. The study aimed to evaluate cathepsins B and L and inhibitor stefin A in relation to their aggressive progression. Patients and Methods: We evaluated 19 adenomas and 10 normal hypophyses. Adenomas were divided according to their histological features and according to their functional activity, e.g. hormones secretion. Irnmunohistochernical labelling was scored for cathepsins and stefin A. Results: High immunohistochemical scores for cathepsins B and L were more frequent in atypical pituitary adenoma. Higher cathepsin B scores were also observed in functional cornpared with non-functional tumours, independently of their histology. Stefin A labelling was observed in 90% of normal hypophyses, but only in 10% of adenomas. Conclusion: The levels of cathepsins B and L antigens are significantly higher in histologically atypical adenomas. Cathepsin B is also a marker of functional activity of the neoplastic glands. Therefore, we propose that this enzyme is evaluated as a diagnostic marker for tumour progression in non-functional adenomas, to distinguish atypical from benign tumours.
Deskriptorji		PITUITARY DISEASES PITUITARY NEOPLASMS ADENOMA CATHEPSINS CYSTATINS PITUITARY GLAND BIOLOGICAL MARKERS CYSTEINE PROTEINASES DISEASE PROGRESSION IMMUNOHISTOCHEMISTRY