Avtor/Urednik		Fantoni, Cecilia; Auricchio, Angelo
Naslov		Cardiac resynchronisation therapy in heart failure
Prevedeni naslov		Atrio-biventrikularna elektrostimulacija srca pri srčnem popuščanju
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 74, št. Suppl 1
Leto izdaje		2005
Obseg		str. I-37-40
Jezik		eng
Abstrakt		Cardiac resynchronisation therapy (CRT) is a new therapeutic approach for a selected group of patients with symptomatic heart failure (NYHA III-IV) despite optimal medical therapy, due to dilated cardiomyopathy of any etiology (LVEF<= 35%, and LVEDD>= 55 mm), who present with electro-mechanical dyssynchrony (QRS>120 msec). Safety and effectiveness of CRT have been demonstrated by several clinical trials, with patients achieving significant improvement in both clinical symptoms as well as functional status and exercise capacity. Furthermore, CRT has reduced morbidity and mortality of heart failure patients. Whether or not heart failure patients candidate to CRT should receive a defibrillator (ICD) back-up remains debatable, although growing evidence is pointing to extensive use of a defibrillator in such a population.
Izvleček		Atrio-biventrikularna elektrostimulacija srca (CRT) je nov način zdravljenja nekaterih bolnikov z izraženim srčnim popuščanjem (NYHA III-N), ki se pojavi kljub ustreznemu zdravljenju z zdravili. Vzrok dilatacijske kardiomiopatije ni pomemben (LVEF<= 35%, in LVEDD>= 55 mm), pač pa je pomembna elektromehanična dissinhronija (QRS >= 120 ms). Varnost in učinkovitost CRT so pokazale številne klinične raziskave, kjer so ugotavljali izboljšanje kliničnih simptomov, fizikalnih parametrov kot tudi telesne zmogljivosti. Ugotovitve kažejo, da CRT zmanjšuje obolevnost in umrljivost pri bolnikih s srčnim popuščanjem. Ni še povsem, jasno, ali naj bi bolniki, ki so kandidati za CRT, hkrati prejeli tudi kardioverter defihrilator (ICD), narašča pa število dokazov, ki nedvomno podpirajo široko uporabo ICD v tej populaciji bolnikov.
Deskriptorji		HEART FAILURE, CONGESTIVE HEART BLOCK DEFIBRILLATORS, IMPLANTABLE