Avtor/Urednik		Glaser, Marjana
Naslov		Kronične levkemije
Prevedeni naslov		Chronic leukemias
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 44, št. 1
Leto izdaje		2005
Obseg		str. 33-41
Jezik		slo
Abstrakt		Leukemias are malignant neoplasms of the hematopoietic system. They are characterized by the accumulation of a malignant clone of cells in the bone marrow and blood, which are afunctional. These cells are resistant to apoptosis, so they proliferate excessively and become accumulated in the bone marrow, leading to anemia, neutropenia and thrombocytopenia. Certain types of leukemia appear only during childhood, others exclusively in adults. Leukemias can be classified regarding the cell line to myeloid and lymphoid leukemias, and regarding their maturity and course of the disease to acute and chronic forms. The aim of this article is to present four chronic leukemias: chronic myeloid leukemia, which belongs to myeloproliferative diseases, and chronic lymphocytic leukemia, hairy cell leukemia and prolymphocytic leukemia, which are lymphoproliferative diseases.
Izvleček		Levkemije so redke rakaste novotvorbe krvotvornega tkiva, katerih značilnost je kopičenje enega klona nenormalnih in posledično nefunkcionalnih krvnih celic v kostnem mozgu in v krvi. Ker celice ne podležejo apoptozi, se kopičijo v kostnem mozgu, zaradi česar se pojavi slabokrvnost, nevtropenija in trombocitopenija. Glede na vrsto celic jih delimo v limfatične in mieloične, glede na razvojno stopnjo levkemičnih celic in potek bolezni pa v akutne (hitro potekajoče) in kronične (dolgotrajne). Namen sestavka je predstaviti štiri najpogostejše kronične levkemije: kronično mieloično levkemijo, ki spada med mieloproliferativne bolezni ter kronično limfocitno levkemijo, dlakastocelično levkemijo in prolimfocitno levkemijo, ki spadajo med limfoproliferativne bolezni.
Deskriptorji		LEUKEMIA, MYELOID, CHRONIC LEUKEMIA, LYMPHOCYTIC, CHRONIC LEUKEMIA, HAIRY CELL LEUKEMIA, PROLYMPHOCYTIC