Avtor/Urednik		Trkaj, Tinkara; Zbašnik, Tina
Naslov		Nemotorični vidiki izklopa pri bolnikih s Parkinsonovo boleznijo
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2004
Obseg		str. 55
Jezik		slo
Abstrakt		Background. Parkinson's disease (PD) is a neurodegenerative disorder caused by degeneration of dopaminergic neurons in substantia nigra pars compacta. Degeneration results in typical motor features (tremor, rigidity, bradykinesia, postural instability). After chronic therapy with L-dopa motor fluctuations develop, which can progress to on-off fluctuations. Clinical observations and theories of fronto-striatal circuits indicate however that not only motor but non-motor impairment and fluctuations (cognitive, affective, autonomic) may also occur. Aim. The aim of the study was to find out, whether the changes in motor functions during on and off are accompanied by fluctuations in non-motor domain (cognitive, affective, autonomic). We wanted to draw attention to non-motor symptoms and states, which are often overlooked in the off state due to severe motor disability, but are important for the patient's management and for the quality of patient's life, nevertheless. Hypotesis. In advanced stages of PD non-motor fluctuations (autonomic, cognitive and affective) do occur along with the motor fluctuations. Non-motor fluctuations are present in all patients. In every individual patient fluctuations occur in all three non-motor areas simultaneously. Methods. The study was implemented as a prospective study. 20 patients with PD, who are on long-term levodopa treatment and experiencing severe on-off fluctuations, were included in the study. Every subject was assessed in on and in off. Motor functions were assessed with UPDRS, cognitive functions with MMSE, SKT and tests for frontal functions, respectively; affective functions with BDI, GDS 30 and Burns anxiety inventory. Studying autonomic functions, sweating was assessed with VAS by the examiner. Other autonomic symptoms were assessed with VAS by patients themselves and blood pressure as well as pulse were measured. (Abstract truncated at 2000 characters).
Deskriptorji		PARKINSON DISEASE COGNITION DISORDERS LEVODOPA AFFECTIVE DISORDERS AUTONOMIC NERVOUS SYSTEM DISEASES PROSPECTIVE STUDIES