Avtor/Urednik		Panagopoulos, I; Mencinger, M; Dietrich, CU; Bjerkehagen, B; Saeter, G; Mertens, F; Mandahl, N; Heim, S
Naslov		Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).
Tip		članek
Vir		Oncogene
Vol. in št.		Letnik 18, št. 52
Leto izdaje		1999
Obseg		str. 7594-8
Jezik		eng
Abstrakt		Although most extraskeletal myxoid chondrosarcomas (EMC) are cytogenetically characterized by the translocation t(9;22)(q22;q12), another subset has recently been identified carrying a t(9;17)(q22;q11). Whereas the t(9;22) is known to result in fusion of the CHN (TEC) gene from 9q22 with the EWS gene from 22q12, creating a chimeric EWS/CHN, the genes involved in the t(9;17) of EMC are unknown. We examined two EMC with t(9;17)(q22;q11) and found that the CHN gene was recombined with the RBP56 gene from 17q11 to generate a chimeric RBP56/CHN. RBP56 has not previously been shown to be involved in tumorigenesis but it encodes a putative RNA-binding protein similar to the EWS and FUS (TLS) proteins known to play a pathogenetic role in several sarcomas. The presence of the RBP56/CHN chimeric gene in EMC with t(9;17)(q22;q11) shows that the N-terminal parts of EWS and RBP56 have similar oncogenic potential making them pathogenetically equivalent in oncoproteins arising from fusions with certain transcription factors.
Deskriptorji		CHONDROSARCOMA DNA, RECOMBINANT TRANSLOCATION (GENETICS) AMINO ACID SEQUENCE BASE SEQUENCE DNA-BINDING PROTEINS NERVE TISSUE PROTEINS NUCLEAR PROTEINS TRANSCRIPTION FACTORS CHROMOSOMES, HUMAN, PAIR 17 CHROMOSOMES, HUMAN, PAIR 9