Avtor/Urednik     Tepeš, Bojan
Naslov     Učinki nesteroidnih protivnetnih zdravil na prebavila in vloga zaviralcev protonske črpalke
Prevedeni naslov     Gastrointestinal side-effects of non-steroidal anti-inflammatory drugs and role of proton pump inhibitors
Tip     članek
Vir     In: Kopčavar-Guček N, Petek D, Rotar-Pavlič D, editors. Kakovostna obravnava bolnika v družinski medicini: izbrana poglavja s področja vodenja bolnika z rakom, bolečino, psihiatrija, ginekologija, angiologija, gastroenterologija in delavnice. Zbornik predavanj 31. srečanje delovnih skupin; 2005 maj 27-28; Ljubljana. Ljubljana: Združenje zdravnikov družinske medicine,
Leto izdaje     2005
Obseg     str. 85-90
Jezik     slo
Abstrakt     Non-steroidal anti-inflammatory drugs (NSAIDs) are among most frequently prescribed drugs in modern medicine. Between 2 and 4 % of patients, taking conventional NSAIDs, wiII experience symptomatic ulcer or potentially life threatening ulcer complications. Approximately 100.000 hospital admittions and 16.000 deaths annually are caused by NSAIDs in the USA. In Slovenia we have approximately 1.000 hospitalization and 40 deaths annually caused by NSAIDs. Serious complications (bleeding, perforations, stenosis) caused by synthesis inhibition of protective prostaglandins E2 and I2, local topic effect of NSAIDs and their negative effect on mucosal adaptation and healing. Three clinical factors, i. e. the presence of the previous gastrointestinal event, current Aspirin use and age over 65 years, have the greatest influence on the development of complications. The use of corticosteroid's and warfarine treatment is also important. The role of Helicobacter pylori and recommendations for treatment are presented. Patients at higher risk of complications need protection with proton-pump inhibitors or a change of conventional NSAIDs for COX-2 inhibitors. Indications for the use of COX-2 inhibitors or proton-pump inhibitors are presented.
Deskriptorji     ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL
PEPTIC ULCER
PEPTIC ULCER HEMORRHAGE
PEPTIC ULCER PERFORATION
ASPIRIN
CYCLOOXYGENASE INHIBITORS