Avtor/Urednik		Cvelbar, M; Uršič-Vrščaj, M; Rakar, S
Naslov		Risk factors and prognostic factors in patients with double primary cancer: epithelial ovarian cancer and breast cancer
Tip		članek
Vir		Eur J Gynaecol Oncol
Vol. in št.		Letnik 26, št. 1
Leto izdaje		2005
Obseg		str. 59-63
Jezik		eng
Abstrakt		Background and Objective: The most important known risk factor for ovarian cancer is the BRCA1-2 mutation, which is clinically often manifested through a positive family history of cancer of the breast and/or ovary. Whether other risk factors and prognostic factors in women with a positive family history of cancer of the breast and/or ovary and/or with BRCA 1-2 mutation are important remains to be elucidated. Recent studies have shown that in the double primary breast and ovarian cancer (DPBOC), BRCA1-2 mutation is present in at least 86% of cases. Therefore, the group of patients with DPBOC, especially with epithelial ovarian cancer and breast cancer, is the most suitable for such an analysis. The aim of this study was to verify the hypothesis that, in this group, some other risk factors, in addition to a specitic family history of cancer, as well as unfavourable pathomorphological prognostic factors, are more expressed than in a control group of patients with sporadic epithelial ovarian cancer only. Methods: We compared the study group of 31 patients with DPBOC (epithelial ovarian cancer) to a control group of 62 patients with a single, sporadic epithelial ovarian cancer and negative specific family history. The data were obtained from the Cancer Registry of Slovenia and from clinical records. For every patient, we filled-in a protocol and analysed the data, comparing other risk factors in addition to specific family history and prognostic, clinical, and pathomorphological factors. Statistical analysis was performed using descriptive statistics, chi-square test and t-test. Multivariate analysis was also planned, but the necessary conditions were not met. (Abstract truncated at 2000 characters)
Deskriptorji		OVARIAN NEOPLASMS NEOPLASMS, SECOND PRIMARY BREAST NEOPLASMS NEOPLASMS, GLANDULAR AND EPITHELIAL AGE FACTORS RISK FACTORS SLOVENIA CASE-CONTROL STUDIES GENES, BRCA1 MUTATION PROGNOSIS