Avtor/Urednik		Popović, Petra
Naslov		Povezanost med avtofluorescenco in funkcijskimi testi mrežnice pri pigmentni retinopatiji
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2005
Obseg		str. 73
Jezik		slo
Abstrakt		Background: Fundus autofluorescence (AF) in patients with retinitis pigmentosa is characterized by the parafoveal ring of increased AF which surrounds the centre as the atrophic changes with reduced AF expand from the periphery. The aim of this study was to evaluate the AF patterns in relation to retinal function, measured by electroretinography and visual fields. Subjects and methods: 33 patients with retinitis pigmentosa with good visual acuity were included in the study. AF imaging of the central retinal area measuring 30°x30° was performed with the scanning laser ophthalmoscope. Patients were divided in two groups according to the pattern of fundus AF. In group 1 (n=21) all patients had a ring of increased AF of different size but no atrophic areas inside the vascular arcades. In group 2 (n=12) there were patients with a ring of increased AF and well-defined atrophic changes at different eccentricities from the fovea. Visual fields with kinetic (Goldmann) and automated (Octopus) perimetry were performed; ISCEV pattern and multifocal ERGs were recorded. The horizontal radius of the ring of increased AF and the smallest eccentricities of areas with reduced AF were compared to preserved visual fields measured with target II/4 of kinetic perimetry and mean sensitivity index of static perimetry. The size of a ring of increased AF was compared to PERG P50 and N95 amplitudes and to response densities of the inner three rings of the mfERG. Some patients performed central visual field testing with microperimetry as well and results were analyzed in relation to AF imaging. Results: Patients in group 1 had on average larger ring of increased AF, better preserved visual fields and both electroretinographic responses. Pattern ERG for a whole group was reduced to 53% of normal amplitude. (Abstract truncated at 2000 characters)
Deskriptorji		RETINITIS PIGMENTOSA VISUAL FIELDS FUNDUS OCULI PERIMETRY ELECTRORETINOGRAPHY FLUORESCENCE OPHTHALMOSCOPY