Avtor/Urednik		Pečovnik-Balon, Breda; Hojs, Radovan; Ekart, Robert
Naslov		Srčnožilne kalcifikacije pri bolnikih s končno ledvično odpovedjo
Prevedeni naslov		Vascular calcifications and the patients with the final kidney failure
Tip		članek
Vir		In: Križman I, editor. Interna medicina 2005: novosti in aktualnosti. Zbornik predavanj 2. kongres Združenja internistov SZD; 2005 okt 21-22; Ljubljana. Ljubljana: Slovensko zdravniško društvo, Združenje internistov,
Leto izdaje		2005
Obseg		str. 169-71
Jezik		slo
Abstrakt		Vascular calcifications are very frequent extraosseous calcifications in patients with chronic renal disease. They occur im the intima and in the media. They are associated with decreased arterial elasticity and increased mortality. The risk factors are among others increased P concentration and the dose of Ca-containing phosphate binders. It is now well established, that vascular smooth muscle cells actively take up phosphate to form bioapatite. This process is associated with a phenotypic transformation of vascular smooth muscle cells during which they express osteoblast markers. Calcification inhibitors are: matrix Gla protein and fetuin-A. Decreased serum fetuin-A concentration is associated with a higher mortality rate in dialysis patients. An important preventive measure for vascular calcification is the substitution of Ca-containing by non-Cacontaining P binders.
Deskriptorji		KIDNEY FAILURE, CHRONIC VASCULAR DISEASES CALCINOSIS