Avtor/Urednik		Rekič, Andreja; Cvenkel, Barbara
Naslov		Comparison of optic nerve head topography in normal eyes using confocal laser scanning tomograph and retinal thickness analyzer
Prevedeni naslov		Primerjava konfokalnega skenirajočega laserskega tomografa in analizatorja debeline mrežnice pri analizi topografije papile vidnega živca pri normalnih očeh
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 74, št. 10
Leto izdaje		2005
Obseg		str. 617-22
Jezik		eng
Abstrakt		Background. To compare optic nerve head topography measurements by Heidelberg retina tomograph I (HRT) and retinal thickness analyser (RTA) and thereby to determine clinical agreement between the devices. To investigate reproducibility of measurements for HRT and RTA. To obtain our own HRT and RTA database for comparison of healthy and glaucomatous eyes. Methods. The study included 100 normal eyes of 50 white adults of both sexes (mean age of 55.5 (SD 9.5) years). Ophthalmologic examination, fundus phatography, HRT and RTA examinations were performed. To determine reproducibility 10 volunteers repeated the examination after a week. For HRT and RTA measurements mean (SD), median, 5th and 95th percentile, range and coefficient of variation were calculated. Differences in topographic parameters between HRT and RTA were tested for significance. Clinical agreement was assessed with "limits of agreement" and reproducibility expressed by repeatability coefficient and itraclass correlation coefficient (ICC). Results. Significant differences (p<0.05) in topographic parameters obtained by HRT and RTA were observed for all parameters except for rim area (p=0.051)and height variation contour (p=0.054). Limits of agreement between HRT and RTA were too wide and clinically important. Repeatability coefficient was good (<0.10) for all HRT parameters except for RNFL cross-sectional area (0.28). Repeatability coefficient was >0.10 for RTA parameters cup area (0.15), rim area (0.19), maximum cup depth (0.13), height variation contour (0.11) and RNFL cross-sectional area (0.14). ICC was good (>90%) for all parameters, except for mean RNFL thickness (89%) for HRT and height variation contour (84%) for RTA. Conclusions. The two devices cannot be used interchangeably. (Abstract truncated at 2000 characters)
Izvleček		Izhodišča. Strukturne spremembe papile vidnega živca in stanjšanje plasti retinalnih živčnih vlaken (PRŽV) se pri glavkomski nevropatiji pogosto pojavijo pred izpadi v vidnem polju. Morfologija papile vidnega živca je zato pomembna pri zgodnjem odkrivanju in spremljanju glavkoma, kar je pripeljalo do razvoja preiskovalnih metod, kot sta konfokalna skenirajoča laserska oftalmoskopija in digitalna laserska špranjska svetilka, ki omogočata objektivno in kvantitativno analizo tridimenzionalnih lastnosti topografije papile vidnega živca in PRŽV. Namen naše raziskave je bil preveriti ijemanje med metodama in njuno zamenljivost v klinični praksi s primerjavo med meritvami topografij papil s konfokalnim skenirajočim laserskim oftalmoskopom, Heidelbergovim tomografom mrežnice I (HRT) in z digitalno lasersko špranjsko svetilko ter analizatorjem debeline mrežnice (RTA). Preverili smo tudi zanesljivost HRT in RTA pri ponovnem pregledu z določitvijo ponovljivosti meritev za obe metodi. Za vrednotenje strukturnih sprememb papile vidnega živca so potrebni zanesljivi in primerljivi podatki za topografske parametre papile pri zdravih očeh. Zato smo želeli pridobiti lastno normativno podatkovno bazo za HRT in RTA za zdrave oči, kar bi omogočilo zgodnje odkrivanje glavkoma pri slovenski populaciji. Metode. V raziskavo smo vključili 100 očes 50 zdravih prostovoljcev (32 žensk in 18 moških), starih od 40 do 75 let (povprečna starost +-9,5 leta), ki so obiskali očesno ambulanto zaradi predpisa očal. Vključitvena merila so bila: starost>40 let, očesni pritisk<21 mmHg, normalno vidno polje, dioptrija, manjša od +-6 dioptrij, prozorni optični mediji in očesno ozadje brez bolezenskih sprememb. Preiskovancem smo razširili zenici z 1-odstotnim tropikamidom. (Izvleček prekinjen pri 2000 znakih)
Deskriptorji		OPTIC NERVE MICROSCOPY, CONFOCAL RETINA