Avtor/Urednik     Blacher, Silvia; Devy, Laetitia; Hlushchuk, Ruslan; Larger, Etienne; Lamande, Noel; Burri, Peter; Corvol, Pierre; Djonov, Valentin; Foidart, Jean-Michael; Noeol, Agnes
Naslov     Quantification of angiogenesis in the chicken chorioallantoic membrane (CAM)
Tip     članek
Vir     Image Anal Stereol
Vol. in št.     Letnik 24, št. 3
Leto izdaje     2005
Obseg     str. 169-80
ISSN     1580-3139
Jezik     eng
Abstrakt     The chick chorioallantoic membrane (CAM) provides a suitable in vivo model to study angiogenesis and evaluate several pro- and anti-angiogenic factors and compounds. In the present work, new developments in image analysis are used to quantify CAM angiogenic response from optical microscopic observations, covering all vascular components, from the large supplying and feeding vessels down to the capillary plexus. To validate our methodology angiogenesis is quantified during two phases of CAM development (day 7 and 13) and after treatment with an antiangiogenic modulator of the angiogenesis. Our morphometric analysis emphasizes that an accurate quantification of the CAM vasculature needs to be performed at various scales.
Deskriptorji     CHORION
ALLANTOIS
CHICKENS
IMAGE PROCESSING, COMPUTER-ASSISTED
NEOVASCULARIZATION, PHYSIOLOGIC