Avtor/Urednik		Smerkolj, Sava; Mašera, Andrej; Ovčak, Zdenka; Glavač, Damjan
Naslov		Single nucleotide polymorphisms (-174 G/C in IL6 and 801G/A in SDF-1 genes) in association with prostate cancer
Prevedeni naslov		Polimorfizma -174 G/C v genu IL6 in 801G/A v genu SDF-1 v povezavi z rakom prostate
Tip		članek
Vir		In: Luzar B, Poljak M, Glavač D, et al, editors. Molekularna diagnostika v medicini. Zbornik 15. spominsko srečanje akademika Janeza Milčinskega, 36. memorialni sestanek profesorja Janeza Plečnika, 1. srečanje Slovenskega društva za humano genetiko z mednarodno udeležbo; 2005 30 nov - 2 dec; Ljubljana. Ljubljana: Medicinska fakulteta,
Leto izdaje		2005
Obseg		str. 315-20
Jezik		eng
Abstrakt		Prostate cancer, despite being an increasingly important problem in developed countries, still remains a target of research because of insufficient knowledge of its genetic basis. A great variety of risk factors and candidate genes have to date been reported in correlation with it. Using TaqMan(R) technology, allelic discrimination for polymorphisms in IL-6, SDF 1, IL-9, CCR3 and PARC genes was performed in a cohort of prostate cancer patients and corresponding controls. In the present study, a statistically significant association was found between non-coding polymorphisms-174G/C in IL-6 and 801 G/A in SDF-1 genes and prostate cancer. Since Interleukin-6 and stromal cell-derived factor 1 are already known to be involved in prostate cancer, both SNPs maybe useful genetic markers for a predisposition to prostate cancer.
Deskriptorji		PROSTATIC NEOPLASMS POLYMORPHISM (GENETICS) POLYMERASE CHAIN REACTION