Avtor/Urednik		Dolžan, Vita
Naslov		Genetski polimorfizmi v presnovi kancerogenov in maligni melanom
Prevedeni naslov		Genetic polymorphism of xenobiotic metabolising enzymes and maligant melanoma
Tip		članek
Vir		In: Miljković J, editor. Strokovno srečanje z mednarodno udeležbo 3. dermatološki dnevi; 2005 nov 11-12; Maribor. Maribor: Splošna bolnišnica Maribor,
Leto izdaje		2005
Obseg		str. 102-12
Jezik		slo
Abstrakt		The skin acts as the first defense barrier from external environmental polutants, including chemicals and UV radiation. It is generally accepted that UV exposure is the main risk for the development of malignant melanoma, but other environmental and genetic factors may modify this risk. Cytochrome P450 CYP1A1 and glutathione S-transferases (GSTs) were found in melanocytes and skin basal layers and were shown to participate both in metabolism of xenobiotics such as PAHs and in detoxification of reactive oxygen species. The aim of this work is to present genetic polymorphisms in detoxification of xenobiotics and reactive oxygene species that could modify the risk for sporadic malignant melanoma. While genetic variability in metabolism of chemical carcinogens was shown to represent a risk factor in a large number of human cancers, especially lung cancer, the role of inherited metabolic susceptibility for skin cancer, especially sporadic malignant melanoma, is not so evident. Although the results of our recent study indicated that in Slovenian population polymorphic genes coding for xenobiotic metabolising enzymes do not play a major role in protection against environmental carcinogenesis in human skin, these genetic polymorphism may confer increased susceptibility for melanoma in individuals with higher exposure to PAHs, either professional or even more importantly due to topical treatment with tar containing ointments in some skin disorders.
Deskriptorji		SKIN NEOPLASMS MELANOMA POLYMORPHISM (GENETICS) CYTOCHROME P-450 GLUTATHIONE TRANSFERASES