Avtor/Urednik		Gradišnik, P; Todorović-Guid, M; Burja, S; Mejaški-Bošnjak, V
Naslov		Epilepsija pri nedonošenih otrocih: ali je pomemben čas nastanka perinatalne poškodbe možganov?
Prevedeni naslov		Epilepsy in premature infants: is the time of perinatal brain damage crucial?
Tip		članek
Vir		In: Burja S, editor. Možgani, ranjeni v zgodnjem razvoju otroka. Zbornik predavanj Mednarodna znanstvena konference Učna delavnica s področja slikovne diagnostike z ultrazvokom; 2005 dec 9-10; Maribor. Maribor: Splošna bolnišnica Maribor,
Leto izdaje		2005
Obseg		str. 50-61
Jezik		slo
Abstrakt		Objective: Epilepsy is a frequent outcome of perinatal brain damage in term newborns. Studies discussing neurological outcome in prematurely born children are mainly oriented towards motor development evaluation. It is now accepted that damage to brain tissue is partly due to prenatal pathological occurrences. It is the concluding process of brain cortex formation going on during the final trimester of pregnancy that opens the possibility of secondary development of cortical brain damage following the primary exposure of white matter. The present study was aimed at establishing whether antepartally developed periventricular damage of brain tissue in prematures can cause early- age onsets of epilepsy. Methods: The research included 105 prematures born during the years 1992-1994 with completed brain ultrasound during the first week. Following the medical documentation we categorized their ultrasound readings according to the measure of brain damage as well as to the approximate time of damage occurrence. The potential prognostic factors were compared with the incidence of epilepsy. Using the binary logistic regression method, the relative risk of the occurrence was established for each of the potential factors. Results: In 48.6% of the children, completely normal brain ultrasound findings were obtained. Instances of brain-tissue damage were localized in periventricular white matter; none of the children had cortical damage ascertainable by ultrasound. In 19% of our patients, an isolated hemorrhagic brain-tissue lesion was found; in 15.2% an isolated ischemic damage; in 17.1% concurring hemorrhagic and ischemic lesions were found. By ultrasound criteria, 37% of the brain damage occurrences were established as antepartal. Severe brain lesions, defined as lesions of the third or fourth degree, were present in 11.4% children. During the 6-8 years of follow-up we ascertained epileptic occurrences in 11.4% of our patients. (Abstract truncated at 2000 characters)
Deskriptorji		INFANT, PREMATURE EPILEPSY CEREBRAL ISCHEMIA RISK FACTORS INFANT, NEWBORN