Avtor/Urednik		Bračko, Matej
Naslov		Gastrointestinalni stromalni tumor (GIST): biološke, patološke in klinične značilnosti
Prevedeni naslov		Gastrointestinal stromal tumors: biologic, pathologic and clinic characteristics
Tip		članek
Vir		In: Omejc M, Repše S, editors. Zbornik simpozija Kirurgija želodca - standardi in novosti; 2005 okt 13-15; Ljubljana. Ljubljana: Klinični oddelek za abdominalno kirurgijo, Klinični center,
Leto izdaje		2005
Obseg		str. 91-7
Jezik		slo
Abstrakt		Gastrointestinal stromal tumor (GIST), the most common mesenchymal tumor of the gastrointestinal tract, is a distinct tumor entity, different from smooth muscle and nerve sheath tumors of the digestive system. GISTs are characterized by the expression of CD117/KIT, which can be detected by immunohistochemistry. The identification of mutations of KIT protooncogene in many GISTs has resulted in a better understanding of their oncogenic mechanisms. Since an effective specific biologic treatment is now available, the diagnosis of GIST must be accurate. This paper briefly reviews the biological, pathological and clinical features of GIST.
Deskriptorji		GASTROINTESTINAL NEOPLASMS MESENCHYMOMA PROTO-ONCOGENE PROTEINS C-KIT IMMUNOPHENOTYPING STOMACH NEOPLASMS IMMUNOHISTOCHEMISTRY