Avtor/Urednik		Cesar, Simona
Naslov		Vpliv sepse na strukturo in funkcijo levega prekata podgane v diastoli
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2005
Obseg		str. 75
Jezik		slo
Abstrakt		Introduction. Sepsis is a syndrome where, presumably as a consequence of excessive mediator release, multiple organs remote from the inciting inflammatory event sustain injury, including the cardiovascular system. There is increasing evidence that sepsis alters myocardial function in clinical and experimental settings. Most investigators have focused on the characterization of systolic dysfunction, but little has been done to address the diastolic function in sepsis. Many authors came to different conclusions about the changes in diastolic nyocardial compliance in sepsis: some suggested a decrease of myocardial compliance, others an increase. Neither the temporal processes of these changes nor the molecular mechanism of the changes are uniformly defined. All studies to date dealing with myocardial dysfunction in sepsis have focused on changes that occur in the structure of myocytes. Since myocardial compliance may be affected by myocardial edema and collagen loss in opposte ways (edema increases stiffness, whereas collagen loss decreases stiffness), the net effect can only be determined by measuring myocardial compliance in this setting. According to our knowledge there are no studies that have sought to correlate histological changes and edema with diastolic dysfunction in sepsis. The goal of the present study was to evaluate the effects of sepsis on left ventricular (LV) compliance by determining the end-diastolic pressure volume relationship (EDPVR) in septic rats on Days 1, 3 and 7 of sepsis and to estimate whether these changes are accompanied by changes in myocardial collagen content and myocardial edema that could affect compliance. (Abstract truncated at 2000 characters)
Deskriptorji		SEPSIS DIASTOLE VENTRICULAR DYSFUNCTION, LEFT MYOCARDIUM COLLAGEN BLOOD PRESSURE MICROSCOPY, POLARIZATION RATS, WISTAR