Avtor/Urednik		Writzl, K; Zorn, B; Peterlin, B
Naslov		Preliminary analysis of AZFb region duplication by quantitative real-time PCR
Tip		članek
Vir		Hum Reprod
Vol. in št.		Letnik 21, št. 3
Leto izdaje		2006
Obseg		str. 753-4
Jezik		eng
Abstrakt		Background: Deletions of the AZFb region on the long arm of the human Y chromosome cause male infertility. However, the reciprocal products of these deletion events, AZFb duplications, have not been reported to date. Furthermore, it is not known whether potential AZFb duplications represent a risk factor for spermatogenic failure. Methods: A total of 150 patients with male idiopathic subfertility (79 non-obstructive azoospermics and 71 oligozoospermics) and 150 fertile men were analysed for deletion/duplication of the sY125 locus and of the JARIDID gene using real-time PCR. Results: Three azoospermic men had deletion of the sY125 locus and of the JARIDID gene. No duplication was detected. Conclusions: In our limited sample, AZFb duplications do not appear to be associated with male infertility.
Deskriptorji		INFERTILITY, MALE Y CHROMOSOME OLIGOSPERMIA CHROMOSOME DELETION SEX CHROMOSOME ABNORMALITIES POLYMERASE CHAIN REACTION