Avtor/Urednik		Osredkar, Damjan; Derganc, Metka; Paro-Panjan, Darja; Neubauer, David
Naslov		Amplitude-integrated electroencephalography in full-term newborns without severe hypoxic-ischemic encephalopathy: case series
Tip		članek
Vir		Croat Med J
Vol. in št.		Letnik 47
Leto izdaje		2006
Obseg		str. 285-91
Jezik		eng
Abstrakt		Aim To assess the diagnostic value of amplitude-integrated electroencephalpgraphy (EEG) in comparison to standard EEG in newborns without severe hypoxic-ischemic encephalopathy who were at risk for seizures. Methods The study included a consecutive series of 18 term newborns without severe hypoxic-isehemic encephalopathy, but with clinical signs suspicious of epileptic seizures, history of loss of social contact, disturbance of muscle tone, hyperirritabllity, and/or jitteriness. Amplitude-integrated and standard EEG tracings were assessed for background pattern, epileptiform activity, and sleep-wake cycling. Results Amplirude-integrated EEG and standard EEG recordings of 15 newborns were suitable for analysis. Only two different background patterns were seen on amplitude-integrated EEG and standard EEG, with the absence of severely abnormal background patterns. Of 15 newborns, epileptiform discharges were present on amplitude-integrated EEG in 3 newborns, and on standard EEG in 6 newborns. Sensitivity of seizures discharges on amplitude-integrated EEG to correspond with eplleptiform discharges on standard EEG was 50%; specificity 100%, positive predictive value 100%, and negative predictive value 75%. Of 4 newborns suspected of having sleep myoclonus, amplitude-integrated EEG correctly identified the newborn who had epileptiform activity on standard EEG. Conclusion The diagnostic value of amplitude-integrated EEG monitoring of term newborns without severe hypoxic-ischemic encephalopathy is limited, but could have a role in evaluating presence or absence of epileptiform activity and in differentiating non-epileptic movement from seizures.
Deskriptorji		EPILEPSY ELECTROENCEPHALOGRAPHY INFANT, NEWBORN