Avtor/Urednik		Rot, Uroš
Naslov		Klinične in paraklinične značilnosti bolnikov v različnih obdobjih multiple skleroze
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2006
Obseg		str. 70
Jezik		slo
Abstrakt		Background. Axonal loss which is already present in patients with clinically isolated syndromes (CIS) and effective immunomodulatory therapy in patients with CIS and relapsing-remitting multiple sclerosis (RR MS) demand early and accurate diagnosis of the disease. The diagnosis is facilitated with detailed knowledge about clinical and paraclinical characteristics of patients in different stages of MS, especially patients with CIS and patients with uncommon course of the disease, as seen in patients with primaryprogressive (PP) MS. Aim of the study was to analyse clinical, MRI, CSF and evoked potential findings of patients in different stages of MS, to compare clinical and paraclinical features in patients with CIS and patients with RR MS, and to analyse findings in patiens with PP MS, especially the agreement of our diagnosis with the new McDonald criteria for PP MS. Patients and methods. Retrospective analysis included 130 patients (90 females) with the diagnoses of MS or CIS with median age 35,5 years and median duration of the disease 2 years. Twenty-seven included patients had CIS, 66 RR MS, 19 secondary-progressive (SP) MS and 18 PP MS. The present and predominant symptoms in patients were determined, as well as EDSS score, brain/spinal cord MRI findings, CSF and visual (VEP) and somatosensory (SEP) evoked potential findings. Results. Fifty-two percent of patients with CIS had predominant sensory symptoms. In later stages of the disease, especially in patients with SP MS motor symptoms were predominant. Patients with SP MS were more disabled and had longer duration of the disease than patients with CIS and RR MS. Fifty-six percents of patients with CIS, 88% of patients with RR MS and 74% of patients with SP MS fulfilled modified Barkhof brain MRI criteria. (Abstract truncated at 2000 characters)
Deskriptorji		MULTIPLE SCLEROSIS MAGNETIC RESONANCE IMAGING EVOKED POTENTIALS, VISUAL EVOKED POTENTIALS, SOMATOSENSORY DISEASE PROGRESSION RETROSPECTIVE STUDIES