Avtor/Urednik		Paragi, Metka
Naslov		Molekularno epidemiološke značilnosti invazivnih sevov bakterije Neisseria meningitidis izoliranih v letih 1993-2003 v Sloveniji
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2005
Obseg		str. 111
Jezik		slo
Abstrakt		Neisseria meningitidis is the major cause of bacterial meningitis, sepsis and other invasive diseases. It can also be the causative agent of local outbreaks, epidemics or even pandemics. Different clone complexes are responsible for meningococcal diseases worldwide. The epidemiological survaillance and typing of bacteria is an important issue of Public health authorities. Since the meningococcus are very contagious, the hypervirulent clones can spread very quickly among people. The spreading is clonal. At present less than 10 clone complexes are resposible for most meningococcal diseases and can provoke epidemic in susceptible population. In the last 10 years, as well as in the previous period, we have noticed fluctuation in the incidence of invasive diseases and also in the frequency of different serogroups (increase of serogroup C). With phenotypic typing we detected also the strain which caused many epidemics in Europe (Czech Republik, 1993). There is a question wheather there is really a new hypervirulent clone present (serogroup C) in Slovenia. In 2000, we also detected serogroup W135 for the first time in Slovenia. Phenotipically it could be the same as hypervirulent clone from Mecca (Hajj strain). We wanted to confirm the genetic linkage also with this clone, which caused epidemics in the countries where pilgrims came from. We presumed that in Slovenia the hypervirulent clones (mostly serogroup C) are already present, threatening adolescents. We presumed also the appareance of hypervirulent Hajj clone from Mecca (serogroup W135) as well as the hypervirulent clones from serogroup B which is the most common in Slovenia. To confirm this hypothesis we used the molecular typing method MLST (Multi Locus Sequence Typing), which is the most appropriate method for the global epidemiology of meningococci and which can exactly confirm the genetic relatedness between the hypervirulent clones and our isolates. (Abstract truncated at 2000 characters)
Deskriptorji		NEISSERIA MENINGITIDIS PHENOTYPE GENOTYPE VIRULENCE MENINGITIS, MENINGOCOCCAL