Avtor/Urednik     Kirbiš, Janez
Naslov     Direktni in serološki dokazi prisotnosti Chlamydiae pneumaniae pri bolnikih z nestabilno angino pektoris
Prevedeni naslov     Direct and serological evidence of the presence of Chlamydia pneumoniae in patients with unstable angina pectoris
Tip     monografija
Kraj izdaje     Ljubljana
Založnik     Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje     2006
Obseg     str. 45
Jezik     slo
Abstrakt     Coronary artery disease (CAD) is a multifactorial disease, which appears to be due to the combination of multiple genetic and environmental factors. We hypothesized that Chlamydia pneumoniae (C pn.) infection (acute, chronic, reinfection) is involved in the pathogenesis of CAD and its complication, acute coronary event (i.e., unstable angina). The aim of this study was to find whether C. pn. infection (acute, chronic, reinfection) or C. pn. DNA infection, demonstrated by the presence of C. pn. DNA in the artery (i.e., aortic) wall, was associated with CAD or acute coronary syndrome. Subjects were enrolled into the prospective study from individuals referred for open heart surgery due to CAD (CAD group, 115 cases: 51 cases with acute coronary syndrome, i.e., unstable angina, and 64 cases with stable angina) or because of aortic valve disease (control group, 52 subjects without angiographic evidence of CAD referred for aortic valve replacement). Blood for serological analysis was taken just before operation, whereas the ascending aorta samples were taken for the demonstration of the C. pn. DNA presence during operation. All the patients were followed until October 2005. Acute infection (MIF IgM titer >= 1:16 or greater, or IgG titer >= 1:512) was observed in 15.7%, of patients with acute coronary syndrome, in 7.8%, of patients with stable angina and 0% in the, control group(p = 0.015); reinfection was not observed at all. Chronic infection (MIF 32 < IgG < 512 or 32 < IgA < 256) was observed in 39.2% of patients with acute coronary syndrome, in 68.7% of patients with stable angina, and 61.5% of control group subjects (p = ns). The presence of C. pn. DNA in the artery (i.e., aortic) wall was associated with a 3.7-fold increased risk of CAD (95% CI 1.2-11.3, p < 0.01). C. pn. DNA was demonstrated in 23.6% of CAD patients, and in 7.7% of control group subjects. (Abstract truncated at 2000 characters).
Deskriptorji     CORONARY DISEASE
ANGINA, UNSTABLE
CHLAMYDIA PNEUMONIAE
IGG
IGG
IGA
POLYMERASE CHAIN REACTION
PROSPECTIVE STUDIES