Avtor/Urednik		Jarc-Vidmar, Martina
Naslov		Morfološke in funkcionalne značilnosti prizadetosti mrežnice pri Bestovi viteliformni distrofiji
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2005
Obseg		str. 85
Jezik		slo
Abstrakt		Background: Best's vitelliform dystrophy is second most common inherited macular dystrophy, that usually starts at an early age and progressively affects patient's central vision. It is clinically heterogenous and pleomorphic disease where ophthalmoscopically visible lesions often do not correspond with deterioration of visual function. The aim of our study was to evaluate central retinal sensitivity by correlating retinal morphology with functional and electrophysiological tests. Patients and methods: 15 patients from five families with different stages of BVD were included in the study. The blood samples were taken for genetic analysis and autofluorescence (AF) was recorded with the scanning laser ophthalmoscope. The central 10° visual fields were tested with static perimetry (Octopus M2 TOP) and microperimetry (MPi, Nidek technologies), that enables one to compare central retinal sensitivity and fixation patterns in relation to the fundus image. The results of MP testing were compared with retinal morphology seen by AF with the Adobe Photoshop programme. ISCEV pattern and mfERG were recorded in all the patients. Results: In initial stages of Best's disease there were localised areas of hyperfluorescence centrally in the fovea, later getting non-homogenous, finally being replaced by central hypofluorescent areas surrounded by hyperfluorescent rings. Based on MP testing and AF three groups of patients were formed. The patients in the first two groups (VA: 0,8 +- 0,1 in 0,5 +- 0,3) were fixating centrally next to relative (Group 1) or absolute (Group 2) scotoma inside the nonuniform hypo- and hyperfluorescent area as seen with AF. Inner parts of the retina close to the fovea were most affected, whereas regions closer to the periphery of the 10° visual field showed near normal function. (Abstract truncated at 2000 characters)
Deskriptorji		MACULAR DEGENERATION PERIMETRY OPHTHALMOSCOPY ELECTRORETINOGRAPHY VISUAL FIELDS FLUORESCEIN ANGIOGRAPHY