Avtor/Urednik		Marčun-Varda, Nataša; Zagradišnik, Boris; Stangler-Herodež, Špela; Kokalj-Vokač, Nadja; Gregorič, Alojz
Naslov		Polymorphisms in four candidate genes in young patients with essential hypertension
Tip		članek
Vir		Acta Paediatr
Vol. in št.		Letnik 95
Leto izdaje		2006
Obseg		str. 353-8
Jezik		eng
Abstrakt		Aim: To determine whether four potential genetic factors (polymorphisms in genes for alpha-adducin, beta-adducin, the G-protein beta-3 subunit and nitric oxide synthase) are important for the development of essential hypertension (EH) in Slovenian children and young adults with EH. Methods: Both a nuclear families approach and case-control study have been performed. Genotyping of common polymorphisms in these genes using polymerase chain reaction was carried out in 104 nuclear families (an affected child, both parents) and in 200 control patients. Results: Using the transmission disequilibrium test, no statistically significant differences were found between the frequencies of transmitted and non-transmitted alleles in nuclear families for all four investigated polymorphisms. In addition, the distributions of genotypes and alleles for the four polymorphisms did not differ significantly between our children and 200 healthy control patients. The allele frequencies of all polymorphisms were concordant with those observed in some other Caucasian populations. Conclusion: We found no association between the investigated gene variants and EH, so we conclude that they do not confer a significantly increased risk of the development of EH in the Slovenian population of hypertensive children.
Deskriptorji		HYPERTENSION POLYMORPHISM (GENETICS) GENOTYPE ALLELES GTP-BINDING PROTEINS NITRIC-OXIDE SYNTHASE POLYMERASE CHAIN REACTION CASE-CONTROL STUDIES CHILD