Avtor/Urednik		Drobnič, M; Radosavljevič, D; Ravnik, D; Pavlovčič, V; Hribernik, M
Naslov		Comparison of four techniques for the fixation of a collagen scaffold in the human cadaveric knee
Tip		članek
Vir		Osteoarthritis Cartilage
Vol. in št.		Letnik 14
Leto izdaje		2006
Obseg		str. 337-44
Jezik		eng
Abstrakt		Objective: Four fixation techniques for a fibrinogen and thrombin coated collagen fleece, used as a scaffold in the cartilage repair, were compared simulating the initial postoperative period in the cadaveric knee joints. Methods Full-thickness chondral lesions were made on the medial femoral condyles of seven human cadaveric inferior extremities. Four scaffolds without seeded chondrocytes were implanted into each lesion using four fixation techniques consecutively: self-adhesion without additional material (SA), fibrin sealant (FS), bone sutures (BS), and periosteal cover (PC). After each implantation 150 cycles of continuous passive motion (CPM) were performed. Two cases were additionally exposed to 50 cycles of 10 and 20 kg loading each after the completion of CPM. The scaffolds were evaluated after every 30 cycles, and the fixation strength was tested after the motion was completed. Results: All the SA scaffolds were detached before 60 cycles. The other scaffolds remained stable throughout the testing with only minor disruptions. The endpoint fixation strength was higher for BS and PC than for the FS scaffolds. The FS scaffolds were detached as a result of additional load cycles, while the BS and PC scaffolds showed substantial deformations. Conclusion: SA of tested scaffold did not provide sufficient fixation. The FS fixation was easy to perform and assured satisfactory scaffold stability. BS and PC provided excellent scaffold stability, but the techniques were difficult and caused additional injuries. Regardless of the fixation technique used, the tested collagen scaffold may not be exposed to loading in the initial postoperative period.
Deskriptorji		KNEE JOINT CARTILAGE, ARTICULAR COLLAGEN TISSUE FIXATION RANGE OF MOTION, ARTICULAR FIBRIN THROMBIN SUTURES RANGE OF MOTION, ARTICULAR CADAVER