Avtor/Urednik		Strniša, Luka; Škerget, Matevž
Naslov		Določitev deleža aktiviranih trombocitov z monoklonalnimi protitelesi za aktivirani fibrinogen in selektin-P pri bolnikih z idiopatično trombocitopenično purpuro in klinični pomen raziskave
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2005
Obseg		str. 39
Jezik		slo
Abstrakt		Background. Idiopathic thrombocytopenic purpura (ITP) is an acquired disorder of blood homeostasis with thrombocytopenia. Diagnosis is one of exclusion. ITP usually runs a mild course and requires no therapy but there are many accounts of fatal bleeding. The incidence of bleeding in ITP patients is lesser than would be predicted on patients' platelet counts. Splenectomy is part of the basic treatment for relapsing ITP patients which brings about longterm remission in 70% of patients. Aim. There are assumptions of higher proportion of activated platelets in the blood of patients with ITP, which could explain the lower bleeding tendencies. In the literature there is no data about the activity of thrombocytes in ITP patients without therapy or with splenectomy. Our study was conducted with the intention of showing whether ITP patients with therapy, or after splenectomy, have a different proportion of activated platelets than that of the healthy population. Our goal was also to consider the significance of measuring the proportion of activated platelets in clinical practice concerning ITP patients. Hypothesis. By measuring the proportion of activated platelets, we tested the following hypotheses: 1 Patients with ITP which have not received any treatment, have a higher proportion of activated platelets in their blood than the healthy population. 2. Splenectomized ITP patients in remission without further treatment have the same proportion of activated platelets in the blood as the healthy population. Methods. The study included 94 subjects, of which there were 37 ITP patients and 57 healthy volunteers. We chose two groups of ITP patients. Those, which had platelet counts lower than 70 X 10 9 /L and were without therapy for the last 3 months, formed the first group. Splenectomized ITP patients in remission, without adjoining therapy, formed the second group. (Abstract truncated at 2000 characters)
Deskriptorji		PURPURA, THROMBOCYTOPENIC, IDIOPATHIC PLATELET COUNT ANTIBODIES, MONOCLONAL FIBRINOGEN P-SELECTIN SPLENECTOMY FLOW CYTOMETRY