Avtor/Urednik		Zupan, Igor
Naslov		Pomanjkljivosti in nove možnosti zdravljenja angine pektoris
Prevedeni naslov		Shortcomings and new perspectives in the treatment of angina pectoris
Tip		članek
Vir		Slov Kardiol
Vol. in št.		Letnik 3, št. 1
Leto izdaje		2006
Obseg		str. 58-61
Jezik		slo
Abstrakt		Stable angina (AP) is a common and disabling disorder that is prevalent in 30.000 to 40.000 per one million population. It persists in many patients despite currently available therapies, including revascularisation. Despite these advances, there remain important unmet medical needs in the treatment of AP. A substantial proportion of patients who are on medicat therapy still experience anginal symptoms. This condition has been named refractory angina pectoris. Current medical therapy has shortcomings, mainly related to insufficient efficacy, lack of hemodynamic tolerance and side effects. Comorbidities and medication tolerability must be considered in the selection of therapy. There is currently little proof of a direct impact of anti-ischemic therapy on clinical outcomes in the context of stable angina. The heart rate seems to be major determinant of myocardial oxygen demand and has shown a strong link with CV morbidity. More studies are needed to explore the impact of antianginal therapies on outcomes in the revascularisation era.
Izvleček		Stabilna angina pektoris (AP) je pogost klinični problem, saj prizadene do 30.000 do 40.000 oseb na milijon prebivalcev. Povzroča težave številnim bolnikom kljub sodobnim zdravilom in kirurškemu zdravljenju. Navzlic velikemu napredku se zdi, da obravnava angine pektoris zasluži večjo pozornost. Znano je, da imajo bolniki angino pektoris tudi po tem, ko že prejemajo ustrezna zdravila v ciljnem odmerku. Govorimo o trdovratni (refraktarni) angini pektoris. Trenutno razpoložljiva zdravila imajo pomanjkljivosti, ki se kažejo v zmanjšani učinkovitosti, stranskih učinkih ali v hemodinamski neprilagodljivosti. Pri izbiri primernega zdravila moramo upoštevati sočasne bolezni in spremljati prenašanje zdravila. Trenutno razpolagamo z malo podatki o direktnem vplivu "antiishemičnih" zdravil na klinični potek bolnikov s stabilno angino pektoris. Kaže, da je srčna frekvenca pomemben pokazatelj porabe kisika v srčni mišici in je v tesni zvezi z obolevnostjo zaradi srca in ožilja. Potrebujemo nadaljnje raziskave, ki bodo pojasnile dileme pri obravnavi bolnikov z angino pektoris.
Deskriptorji		ANGINA PECTORIS